DOCK4 and dentin dysplasia: In this study, we report seven individuals with an overlapping phenotype of mild to severe DD/ID, harboring different variants in DOCK4. We used structural in silico modeling and a neurite outgrowth assays with Neuro-2A cells that were transiently transfected with an overexpression plasmid for DOCK4 or after CRISPR-Cas9-mediated Dock4 knockout to assess possible impact of the variants.