Then, we constructed amino acid metabolism profiles by WGCNA and LASSO regression model for investigating the impact of amino acid metabolism on pheochromocytoma pathogenesis and immunity and identified six hub genes (DDC, SYT11, GCLM, PSMB7, TYRO3, and AGMAT). Here, PSMB7 is linked to hereditary pheochromocytoma-paraganglioma.