Then, we constructed amino acid metabolism profiles by WGCNA and LASSO regression model for investigating the impact of amino acid metabolism on pheochromocytoma pathogenesis and immunity and identified six hub genes (DDC, SYT11, GCLM, PSMB7, TYRO3, and AGMAT). This evidence concerns the gene GCLM and hereditary pheochromocytoma-paraganglioma.