We found that high-risk patients had lower levels of antitumor-infiltrating immune cells, whereas, the low-risk group had higher populations of antitumor immune cells in the tumor microenvironment (e.g., B cells, CD8 T cells, NK cells, dendritic cells (DCs), mast cells, neutrophils, T follicular helper cells), which indicated globally impaired immune function in the GEO cohort of high-risk patients. Here, CD8A is linked to neoplasm.