TP63 and head and neck squamous cell carcinoma: TP63 is detected in approximately 80% of HNSCCs; ΔNp63 is predominantly implicated in the pathogenesis of HNSCC, modulates critical pathways such as cell survival and renewal, inhibits senescence by repressing p16/INK4A, and governs growth factor signaling (Si et al. 2016; Rocco et al. 2006).