PIK3CA and head and neck squamous cell carcinoma: Moreover, PI3K/Akt/mTOR pathway disruptions are commonly observed in HNSCC, with mutations in the PIK3CA gene present in approximately 16% of cases, suggesting that this gene is a potential target for therapeutic intervention (Kang et al. 2015). Recent days, the prognostic model based on varies omics data for HNSCC were also generated.