Several studies have reported the prognostic value of the MYH family genes MYL1, MYL2, MYH1, MYH2, and MYH7, which are unfavorable prognostic markers in HNSCC and might promote CD4 + T-cell activation (Li et al. 2023; Ju et al. 2023). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.