Highly SNHG15-expressing cancer cells interacted with M2 macrophages at a higher frequency and intensity, and the key receptor-ligand pairs between them were mainly NRXN3-NLGN1/NRXN1-NLGN1/NRG3-ERBB4/NRG1-ERBB4. Here, NRXN1 is linked to cancer.