As a result, 11 candidate hub genes were obtained, including CTD-2006C1.2, RP4-785G19.5, SNHG1, LRP4-AS1, ZFAS1, RP11-290L1.5, FOXC2-AS1, SNHG5, PXN-AS1, CCNT2-AS1, and SNHG15. The clinical data of patients with nephroblastoma were downloaded from the TARGET database. The gene discussed is FOXC2; the disease is Wilms tumor.