CD8A and cancer: The different cell clusters were annotated by finding marker genes through the "singleR" package (v1.8.1), CellMarker database, and PanglaoDB database (Fig. 6A), resulting in 10 cell clusters, namely B cells, cancer cells, M2 macrophages, regulatory T cells, plasma cells, monocytes, CD8+ T cells, monocytes, fibroblasts, and epithelial cells (Fig. 6B, C) [33].