Both a low-iron diet (35 mg/kg iron) and a chow diet including an iron chelator were able to rescue the reduced insulin sensitivity and β-cell function in the ob/ob mouse model of type-2 diabetes [41] suggesting that the placenta has the ability to protect the fetus from hepcidin-mediated iron deficiency in obese or overweight pregnant women by a compensatory upregulation of placental TFR1 [42]. Here, TFRC is linked to nutritional disorder.