GPX4 and metabolic disease: However, unlike that rat model of metabolic disease, which showed significantly augmented oxidative stress [87], the mRNA expression of anti-ferroptosis genes, including Gclc, Gss and Gpx4 [88] and other pro-ferroptosis genes, such as Acsl4 [89], were not significantly altered in the placentas from HFHS diet-fed mice at either gestational age.