Consistent with LAMC2 promoting EGFR translation, EGFR IHC staining in Cohort 4 showed a significantly higher staining score in iCCA tumors compared to bile ducts (p < 0.001) and a positive correlation with LAMC2 staining in iCCA tumor tissues (p = 0.05) (Figure 8C). Here, LAMC2 is linked to infantile convulsions and choreoathetosis.