KRT19 is a well‐known biliary differentiation marker and presents a high expression level in iCCA.[13] For LAMC2, a few articles reported that it was up‐regulated in CCA, contributed to invasive features of CCA cells, and was related to poor prognosis of patients.[14] Therefore, LAMC2 was chosen for further exploration since its function remained largely unknown in iCCA carcinogenesis. This evidence concerns the gene KRT19 and cholangiocarcinoma.