As a laminin family member, LAMC2 was known to regulate cell invasion, migration, and tumor metastasis in several cancers including CCA.[14, 17, 27] Meanwhile, several recent studies reported its role in promoting cell proliferation in ovarian cancer and pancreatic cancer.[28, 29] Mechanistically, few of these studies suggested a link between LAMC2 and AKT signaling and a possible regulation between EGFR signaling and LAMC2. Here, EGFR is linked to cholangiocarcinoma.