Knockout mice lacking any of the three chains exhibited symptoms similar to human JEB and died within a few days after birth.[33, 34] Considering these phenotypes observed in LAMC2‐knockout animals, it might be feasible to further investigate knocking down LAMC2, as we have done in this manuscript, or suppressing LAMC2’s function in ER via other methods as the safe and suitable strategies to treat iCCA. The gene discussed is LAMC2; the disease is infantile convulsions and choreoathetosis.