Following mammalian SCI, and during pathological conditions like cancer or neurodegenerative disease, P2X7 receptor expression increases (Chong et al., 2010; Giuliani et al., 2014; Martin et al., 2019; Ollà et al., 2020; Pegoraro et al., 2020; Yiangou et al., 2006). This evidence concerns the gene P2RX7 and neurodegenerative disease.