On April 21, 2022, the Centers for Disease Control and Prevention (CDC) issued a health advisory recommending that clinicians consider adenovirus testing in pediatric patients with hepatitis of unknown etiology and that patients meeting the following criteria be reported to jurisdictional health departments: <10 years of age with hepatitis manifested by elevated (>500 U/L) aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and onset since October 1, 2021 (3). The gene discussed is GPT; the disease is hepatitis A virus infection.