YEATS4, also known as GAS41, was originally found to be amplified in glioblastomas.[10] Emerging studies have shown that YEATS4 is essential for cell survival, cell growth, and p53 pathway regulation.[11] Despite realizing the critical role of YEATS4 in cancers, a targeting strategy for this protein remains unavailable due to the poor understanding of how YEATS4 is regulated in cancers. Here, TP53 is linked to cancer.