Inhibition of KAT8 by MG149 suppresses YEATS4 acetylation, leading to an increase in HUWE1 binding to YEATS4, and therefore facilitating HUWE1‐mediated YEATS4 ubiquitination and proteasomal degradation, which subsequently reduces DNA repair and tumor growth and enhances DDP sensitivity (Figure 8). This evidence concerns the gene YEATS4 and neoplasm.