Enhanced DNA repair or inhibition of apoptosis are potential mechanisms of DDP resistance.[33] Interestingly, in our study, blockade of YEATS4 acetylation at K64, 65, 69 by pharmacological inhibition of KAT8 with MG149 impaired DNA repair efficiency and increased DDP‐induced apoptosis of BC cells and consequently sensitized BC cells to DDP. This evidence concerns the gene KAT8 and breast cancer.