DDP‐based chemotherapy is the first‐line treatment for patients with muscle‐invasive and metastatic bladder cancers, yet the clinical efficacy is unsatisfying due to acquired DDP resistance.[5, 27] Interestingly, the DDP‐induced cell apoptosis was significantly increased in YEATS4 3KR cells compared to YEATS4 WT cells (Figure 7A; Figure S6A, Supporting Information). Here, YEATS4 is linked to urinary bladder cancer.