It was demonstrated that SVBP (CCDC23) formed a complex with Vasohibins (VASH1), leading to the dispersion in the cytosol and extracellular release of VASH1, which was identified as a regulator of angiogenesis and cancer cell functions,39 and premature stop codon SVBP variant impaired VASH1 secretion and solubility.40 This evidence concerns the gene SVBP and cancer.