Interestingly, in acute MI and ischemic stroke, the expression of APAF1 and IRAK3 was negatively correlated with the abundance of NK cells, while the expression of ATM, CAPN1, IL1B, IL1R1, PRKACA, PRKACB and TNFRSF1A was positively correlated with the abundance of NK cells in MI.26 The gene discussed is APAF1; the disease is ischemic stroke.