The hub genes identified were IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN and IL1B was the crucial genes among them.IL‐1B is a key pro‐inflammatory cytokine that is associated with the development of atherosclerosis and MI.23 This evidence concerns the gene CDH2 and atherosclerosis.