Breast cancer is a heterogeneousdisease because the underlying cause, response to treatment, and diagnosisof hormone receptor-positive and negative breast cancers differ.7 Women who consumed more flavan-3-ols had a reducedrisk of ER2, but not ER+, breast cancer.5 One member of flavonol is epigallocatechin gallate (EGCG). The gene discussed is NR4A1; the disease is breast cancer.