USP2 and cardiac hypertrophy: 36). In addition, by comparing the GEO dataset and the mRNA level of USP2 in hypertrophic heart induced by trans-arterial coarctation (TAC), it was determined that the expression of USP2 was downregulated in hypertrophic heart, and the overexpression of USP2 could relieve the cardiac hypertrophy induced by TAC. However, further research was still warranted to explore the molecular mechanism of USP2 in myocardial hypertrophy caused by pressure overload (Ref. 37).