AKT1 and cardiac hypertrophy: 72). Li et al. identified UCHL1 as a pathogenic factor of cardiac hypertrophy through microarray analysis. By recognizing and cutting the ubiquitin chains connected with EGFR, UCHL1 reduced the degradation of EGFR through the ubiquitin-proteasome system, thus continuously activating EGFR, Akt and ERK signalling pathways, leading to myocardial hypertrophy (Ref. 9).