PTEN and breast cancer: Additional genes that, during the years, have been implicated in BC pathogenesis include PTEN [12], TP53 [13], CDH1 [14], STK11 [15], CHEK2 [16], PALB2 [17], ATM [18], RAD51C [19], RAD51D [20], BARD1 [21], NF1 [22], BRIP1 [23], CASP8, CTLA4, NBN, and, possibly, CYP19A1, TERT and XRCC3 [24].