Hyperglycaemia alone or in combination with oxLDL treatment upregulated TLR4 gene expression, and the combined effect was synergistic (Figure 3A, NG oxLDL(−), NG oxLDL(+), HG oxLDL(−), HG oxLDL(+); 1.00 ± 0.07, 0.98 ± 0.09, 1.94 ± 0.19, 2.64 ± 0.19). The gene discussed is TLR4; the disease is Hyperglycemia.