Fifita et al. analyzed whole exosome sequence data from 74 ALS patients and identified a novel mutation in the optineurin gene (OPTN) that is found in less than 1% of FTD/ALS patients: expression of the OPTN mutant in motor–neuron–like NSC–34 cells resulted in Golgi fragmentation and a novel heterozygous missense mutation in OPTN (c.883G > T, p.Val295Phe) also caused Golgi fragmentation [72]. Here, OPTN is linked to amyotrophic lateral sclerosis.