Mutations in the gene encoding aminoacyl–tRNA–synthase–complex–interacting multifunctional protein 2 (AIMP2) are responsible for hypomyelinating leukodystrophy 17 (HLD17), a condition characterized by myelin dysplasia and oligodendrocyte shedding. Here, AIMP2 is linked to leukodystrophy, hypomyelinating, 17.