WHRN and sensorineural hearing loss disorder: (8) The study by Chien et al. was excluded because, although targeting an autosomal recessive non-syndromic form of SNHL, i.e., the whirler (whrnwi/wi) mouse, a naturally-occurring model of DFNB31, and delivering gene therapy through an AAV vector, it does not show improved hearing sensitivity at any frequency according to ABR measurements in whirler mice that received whirlin gene therapy despite the restoration of whirlin expression in hair cells in neonatal mice [23].