(2) For the same reason, the studies by Yoshimura et al. and (3) Iwasa et al. reporting the prevention of progressive hearing loss in a mature murine model of human TMC1 deafness and the rescue of hearing in a TMC-1 related hearing loss mouse model through a mutation-agnostic RNA interference with engineered replacement were excluded [17,18]. The gene discussed is TMC1; the disease is hearing loss disorder.