GJB2 and hearing loss disorder: (7) The study by Maeda et al., although it shows that it may be possible to decrease the expression of the mutant allele and modify the deafness phenotype by RNAi protecting against hearing loss, was excluded because it targets an autosomal dominant form of GJB2 hearing loss, in particular the R75W mutation, and because it tested a RNA interference gene therapy by not using an AAV vector [22].