To evaluate the efficacy of exosome-associated AAV vectors in treating TMHS-associated deafness, György et al. utilized a mouse-codon-optimized gene encoding LHFPL5 with a hemagglutinin (HA) tag at the N terminus, which was cloned into an AAV vector backbone under the CBA promoter. The gene discussed is LHFPL5; the disease is deafness.