The metabolic and vascular benefits offered by AT to the lipodystrophic Seipin/Apoe dKO mice were probably attributed to the functionality of the implanted exogenous fat grafts, rather than the improvement of primary lipodystrophy of the recipient Seipin/Apoe dKO mice, as the volume and gene expression of the endogenous adipose were not significantly changed after AT. Here, APOE is linked to lipodystrophy.