APOE and lipodystrophy: Furthermore, AT inhibited lipodystrophy-associated increase of plaque macrophage infiltration and aortic expression of proinflammatory cytokines (Mcp-1, Il-1β, and Il-6) in Seipin/Apoe dKO mice, as shown by CD68 immunohistochemical staining (Fig. 4, E and F) and real-time quantitative PCR analysis (Fig. 4G), respectively.