Moreover, AT significantly reduced lipodystrophy-induced increase of liver weight (Fig. 2B) and hepatic lipid accumulation in Seipin/Apoe dKO mice, as indicated by less lipid vacuoles seen in H&E staining (Fig. 2C) and decreased triglyceride contents using hepatic lipid extraction (Fig. 2D), Meanwhile, AT significantly inhibited lipodystrophy-induced increase of hepatic malondialdehyde (MDA) concentration, a marker of lipid peroxidation level, in Seipin/Apoe dKO mice (Fig. 2E). Here, APOE is linked to lipodystrophy.