APOE and Insulin resistance: Here, using atherosclerosis-prone Seipin/Apoe dKO mice as a lipodystrophic mouse model, we showed that AT partially restored adipose function and markedly improved lipodystrophy-associated metabolic disorders, including hyperlipidemia, hepatic steatosis, and insulin resistance, followed by subsequently reduced atherosclerosis, although no significant improvement of PVAT abnormality or vascular dysfunction was observed.