HAVCR2 and lung adenocarcinoma: TIM3 also modulates the function of NK cells in many human diseases.[28] TIM3 signaling blockade can increase the cytotoxicity and IFN-γ production of peripheral NK cells in patients with lung adenocarcinoma.[29] In our previous study, we found that the expression of TIM3 on NK cells significantly decreased in newly diagnosed SAA patients, which was a potent cytotoxicity negative regulator of some immune cells.[15] When stimulated by cytokines, TIM3 expression on NK cells increased, as well as IFN-γ.