AKT1 and gastric cancer: IGF2BP3 knockdown significantly inhibits cell proliferation and invasion.[142] In addition to the YTHDF and IGF2BP protein families, EIF3B is strongly associated with proliferating cell nuclear antigen expression and PI3K/AKT/mTOR pathway activity in GC samples.[134] hnRNPA2B1 controls the selective splicing of the antiapoptotic factor BIRC5, which promotes cell proliferation, inhibits apoptosis and enhances cell metastasis in GC, and its overexpression is associated with low survival.[144]