EZH2 and gastric cancer: In addition to the above writers, FTO is confirmed as an independent risk factor for predicting the overall survival (OS) of GC.[150] FTO promotes GC metastasis by upregulating the expression of Integrin b1 (ITGB1) through demethylation.[122] ALKBH5, another demethylase, influences the expression of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1), and the overexpression of NEAT1 leads to overexpression of enhancer of zeste homolog 2 (EZH2), a subunit of the polycomb repressive complex, which subsequently affects GC invasion and metastasis.[126]