As reported, ferroptosis induction in keloid fibroblasts was able to attenuate keloids.[159] Furthermore, ACSL4 inhibition was found to prevent inflammatory macrophage ferroptosis and alleviate skin fibrosis in systemic sclerosis.[160] Despite limited evidence, ferroptosis is undeniably one of the important mechanisms leading to skin fibrosis. The gene discussed is ACSL4; the disease is keloid.