Conversely, the downregulation of certain HMTs, such as SET domain containing 8 (SETD2), a tumor suppressor gene significantly reduced in lung cancer, leads to decreased regulation of H3K36me3 modifications, affecting the activity of the signal transducer and activator of transcription 1/interleukin-8 (STAT1/IL-8) signaling pathway. The gene discussed is CXCL8; the disease is lung carcinoma.