IDH2 and central nervous system cancer: These include “diffuse midline gliomas (H3 K27-altered)”, “diffuse hemispheric gliomas (H3 G34-mutant)”, “diffuse pediatric-type high-grade gliomas (H3-wildtype and IDH-wildtype)” and “infant type hemispheric gliomas (ALK, MET, NTRK 1/2/3 or ROS1 fusion)” (10).