95%CI 1.02-1.09), tumor size (HR 3.19, 95%CI 1.57-6.47), histological differentiation grade (poorly differentiated/undifferentiated vs. well-differentiated: HR 3.98, 95% CI 1.37-11.55), TNM stage (stage IV vs. I: HR 29.50, 95%CI 7.62-114.18), Ki67 (HR 2.74, 95%CI 1.41-5.35), and LMR (HR 0.50, 95%CI 0.26-0.96). This evidence concerns the gene MKI67 and neoplasm.