This notion has been recommended and endorsed by all the major professional organizations in the field and can be summarized as follows: “Laboratories should ensure that test results that are unexpected, discordant, equivocal, or otherwise of low confidence are confirmed or resolved using an alternative method or sample.”43 Therefore, in this RETING study, we wanted to explore the performance of typically used single-gene RET assays as potential complementary tools to NGS in testing workflows for patients with advanced NSCLC.6 Here, RET is linked to non-small cell lung carcinoma.