Wound healing fibroblast clusters included populations displaying high Spp1, En1, Mest, and Crabp1 expression, which were not consistently observed in skin cancer CAFs; on the other hand, skin cancer CAFs showed fibroblast populations expressing high levels of complement, Meg3, Lrrc15, and Rgs5, which were not reported in wound healing CAFs. Here, MEST is linked to skin neoplasm.