EPAS1 and neoplasm: VCAFs expressed vascular regulators such as Notch3, Epas1, Col18a1, Nr2f2 and were located in the tumor core near vasculature, while myCAFs expressed many ECM genes, such as glycoproteins (Dcn, Lum, and Vcan), Col14a1, Fbln1, Fbln2, Smoc, Lox, Loxl1, and Cxcl14. DCAFs had strong expression of stem cell genes (Scrg1, Sox9, Sox10, CD10, Gpr77), were near the tumor-stroma boundary, and could be derived from post-EMT tumor cells.