Matrix CAFs in SCC, BCC, and melanomas expressing high levels of COL1A1, COL1A2, COL3A1, LUM, POSTN, TNC, COL11A1 and PTGDS were a larger constituent of benign tumors, while higher numbers of iCAFs expressing MMP1, MMP3, IL6 CXCL8, and IDO1 and different chemokines were correlated with advanced disease (Agnes et al., 2023). The gene discussed is MMP3; the disease is melanoma.