Melanoma CAF subpopulations usually include iCAFs and myCAFs, however, a number of other unique clusters have been put forth including, distinct ECM and contractile CAFs in (Davidson et al., 2020), Wif1 and Zeb2 subpopulations (Filipescu et al., 2023), and matrix and RGS5 (Agnes et al., 2023). Here, ZEB2 is linked to melanoma.