COL1A1 and neoplasm: Hallmark pathway analysis confirmed that CTHRC1 and FAP myCAF cluster was most associated with pro-tumorigenic angiogenesis, EMT, hypoxia, and PI3K/AKT/mTOR signaling (Deng et al., 2022); and the myCAF (FAP, COL1A1,COL1A3) cluster may be critical for tumor growth and metastasis.