Age 18–80 years oldECOG PS 0–2Histological confirmation of prostate acinar adenocarcinoma with a minimum of 10 biopsy cores taken by prostate biopsyPatients belonging to unfavorable intermediate group according to the D’Amico/NCCN risk group classification:Grade Group 3 or/and2–3 risk factors for intermediate category (PSA 10–20/Grade Group 2–3/cT2a cT2b) or/andBiopsy cores positive ≥50%Patients belonging to a subclass of high-risk group according to the D’Amico/NCCN risk group classification:ISUP Group 4 (GS 4 + 4, 3 + 5, 5 + 3) orcT3a stage orPSA >20. This evidence concerns the gene KLK3 and prostatic acinar adenocarcinoma.