STAT3 and Huntington disease: In addition, we noticed that cilostazol disrupts the Interleukin 6 (IL-6)/Janus activated kinase 2 (JAK2)/signal transducer and activator of transcription-3 (STAT3)/suppressor of cytokine signaling (SOCS3) pathway in brain injury in Huntington’s disease, causing the destruction of BBB and increasing the density of blood vessels in rats [10].