Due to its enhanced stability and lipophilicity, ADU‐S100 activates STING signal transduction with higher efficiency than endogenous or exogenous CDNs, and it was proven to have a good tumor elimination effect in melanoma (B16), breast cancer (4 T1), colon cancer (CT26), and other mouse tumor models.350. The gene discussed is STING1; the disease is colonic neoplasm.