For example, the DENV protease complex NS2B3 can cleave cGAS to prevent it from being activated by mtDNA during infection,181 while the Vaccinia virus (VACV) F17 protein causes an imbalance in the mTOR signaling pathway, leading to enhanced degradation of cGAS (and impaired cytosolic DNA‐dependent activation of cGAS–STING signaling at later stages of infection).182. This evidence concerns the gene CGAS and infection.