More interestingly, RNF26, another E3 ubiquitin ligase, competes with RNF5 by catalyzing cGAS K11‐linked polyubiquitination at K150, thereby protecting STING from degradation and maintaining rapid and effective induction of IFN‐I and proinflammatory cytokines after virus infection.144. The gene discussed is STING1; the disease is viral infectious disease.