Mutation or deficiency of the TREX1 gene can cause a series of human autoimmune diseases, including Aicardi‐Goutières syndrome (AGS), systemic lupus erythematosus (SLE), familial lupus erythematosus (FLE), and retinal vasculopathy with cerebral leukodystrophy (RVCL).238, 239. The gene discussed is TREX1; the disease is Aicardi-Goutieres syndrome.