FOXP3 regulatory T (Treg) cells maintain immune homeostasis by producing anti-inflammatory factors like IL-10 and the transforming growth factor TGF-β to suppress excessive immune responses, and their dysregulation has been associated with a wide range of human diseases, such as autoimmune disorders allergies and cancer (Jung et al., 2017). The gene discussed is TGFB1; the disease is allergic disease.