ESR1 and colorectal carcinoma: Consequently, we employed univariate, multivariate, and two-step MR to delve into the potential causal links between ASB consumption and ORCs, encompassing liver, thyroid, CRC, ovarian, breast (combined), estrogen receptor-positive (ER+) breast, ER- breast, esophageal, gastric, pancreatic, endometrial, kidney, and prostate cancers.