To study BEC-to-hepatocyte transdifferentiation during liver injury, we generated a mouse model, Fah-LSL, where Fah is deleted; thus, hepatocyte senescence occurred during liver regeneration, human hereditary tyrosinemia type I caused by FAH deficiency was modeled (Nobili et al.2010), and BEC-to-hepatocyte transdifferentiation was induced. The gene discussed is FAH; the disease is tyrosinemia type I.