ADH1B and neoplasm: Consistent with the secretome, the characterization of the adCAFs implicates it to be more inflammatory-like, resembling the recently discovered ADH1B+ CAFs from Grout et al.26 It is well-known that the secretome of CAFs can be highly influenced by the tumor microenvironment, such as hypoxia or different tumor cell interactions influencing the secretome and even inducing transitioning of CAFs into different phenotypes.30,57