IL6 and metabolic dysfunction-associated steatotic liver disease: The pathogenesis of NAFLD was initially described with the ‘two-hit’ hypothesis, with steatosis, i.e. the accumulation of triglycerides (TAGs) in the liver, representing the ‘first hit’ and triggering the expression of pro-inflammatory cytokines (e.g. NF-a, IL-6) which was described as the ‘second’ hit (16).