Of note the renaming of NAFLD as MAFLD or MASLD has recently been proposed, with new proposed diagnostic criteria, namely hepatic steatosis based on histological (biopsy), imaging or biochemical confirmation along with one of the following: (a) overweight/obesity; (b) T2DM; or (c) metabolic dysfunction as indicated by 2 of the following: increased waist circumference, hypertension, elevated triglycerides, low HDL, prediabetes (IGT, IFG), HOMA index>2.5, elevated CRP, which rather put a positive diagnosis and not an exclusion of other causes of liver disease (10). This evidence concerns the gene CRP and metabolic dysfunction-associated steatotic liver disease.