PAD2 and PAD4 enzymes participate in the formation of NETs by neutrophils and macrophages via caspase 11-dependent pyroptosis [31], promote neutrophil extravasation and accumulation, and NET formation in lung tissue, contributing to endothelial and lung damage in COVID-19 [8,9,[13], [14], [15]]. This evidence concerns the gene PADI2 and COVID-19.