However, the haplotypic combination GTACC between SNPs of PADI2 [rs1005753, rs2235926] and PADI4 [rs11203366, rs11203367 and rs874881] was associated with susceptibility for severe COVID-19 (OR = 1.59, p = 0.007), as well as with susceptibility to present a PLR index ≥303 (OR = 1.93, p < 0.001) (Fig. 2A). Here, PADI2 is linked to COVID-19.