F2 and blood coagulation disease: Elevated coagulopathy markers such as platelets, D-dimer, prothrombin time, and fibrinogen are also strongly associated with severe COVID-19 [47], particulary has been detected in patients with inflamatory disease that fibrinogen is a sustrate for PAD2 and PAD4 [48], this markers are predictors of COVID-19 severity [49], need for admission to intensive care, requirement of IMV during hospitalization [49,50], and mortality [51].