EGF and lung adenocarcinoma: Nucleus–mitochondria sites of membrane contact formed by mitofusin-2 tethers have been described in synchronized A549 cells (human lung adenocarcinoma cells) in response to serum plus epidermal growth factor (EGF) and in HFF-1 cells (human foreskin fibroblasts) in response to hypoxia; both of which induce proliferation (Zervopoulos et al., 2022).