We examined the expression pattern of marker genes associated with activated and degranulated MCs, specifically FCER1G, BTK, and GATA2. We found that these marker genes were also significantly elevated in the MCs population of the keloid group compared to the MC population of the MS group, suggesting a potential association between keloid pathogenesis and stressed state of MCs (Figure 3D) (36–38). This evidence concerns the gene FCER1G and keloid.