By analyzing the reactivity of a TCR from a lesional psoriatic CD8+ T-cell clone rearranging the Vα3S1 and Vβ13S1 variable region genes characteristic of infiltrating lesional CD8+ T cells (Vα3S1/Vβ13S1 TCR) (5, 7), we had previously established as an underlying pathomechanism in psoriasis that HLA-C*06:02 may mediate an autoimmune response against melanocytes, and we had identified an epitope from ADAMTS-like protein 5 (ADAMTSL5) as a melanocyte autoantigen presented by HLA-C*06:02 (13, 14). The gene discussed is HLA-C; the disease is psoriasis.