To investigate whether, according to the polyspecificity of the Vα3S1/Vβ13S1 TCR, the same CD8+ T cells in psoriasis patients can recognize both the ADAMTSL5 peptide and environmental antigens, we employed fluorescent HLA-C*06:02 tetramers loaded either with the ADAMTSL5 or the wheat peptides to stain CD8+ T cells from HLA-C*06:02+ psoriasis patients and healthy individuals. This evidence concerns the gene CD8A and psoriasis.