Since the psoriatic autoimmune response is restricted by HLA-C*06:02 (13) and mediated by CD8+ T cells (8), we analyzed the antigen-induced T-cell proliferation of PBMC by [3H]-thymidine in combination with activation-induced CD137 expression on CD8+ T cells (Supplementary Figure S3), which are the actual pathogenic T cells in psoriasis (8). This evidence concerns the gene CD8A and psoriasis.