CREB1 and systemic lupus erythematosus: Moreover, crucial transcriptional regulators related to lupus such as HDACs/Sin3A, cAMP-responsive element-binding protein (CREB), and nuclear receptor corepressor 1 (NCoR1) were upregulated in both B6.Mecp2Tg1 and MRL/lpr when compared to B6 controls (Figure 8B–D).