TNF and cancer: In parallel with considerable overproduction of other pro-inflammatory modulators, such as TNFα, IL-2, IL-6, MIG (CXCL9), MIP-1β (CCL4) and MIP-2 (CXCL2), we also detected a significantly lower secretion of IL-10 by tILC2s that contradicted the conventional ILC2 role in cancer (22, 23).