TNF and rheumatoid arthritis: Figure 4B showed the correlation between the top 10 biological functions and genes. According to the KEGG pathway enrichment analysis, the Cytokine-cytokine receptor interaction, Th17 cell differentiation, Rheumatoid arthritis, IL-17 signaling pathway, TNF signaling pathway, and other pathways were found to be highly associated with immune response and inflammation (Figure 4C).