Studies have shown that the presence of hypercalcemia at the time of diagnosis is associated with poorer prognosis and patients with DLBCL who present with hypercalcemia often have advanced disease, extensive extranodal involvement, more B symptoms, higher levels of LDH and β2‐microglobulin as well as lower levels of albumin and hemoglobin [12,13]. Here, HLA-G is linked to hypercalcemia disease.