The mean values for BOP and periodontal disease PD were significantly higher in the CD group compared to controls. Additionally, the expression of interleukin-10 was significantly elevated in both the CD and UC groups. The expression of matrix metallopeptidase-7 was also notably higher in the CD group. Participants with IBD who were treated with TNF inhibitors showed a significant overexpression of interleukin-10, as did those on other immunosuppressants, compared to controls. This evidence concerns the gene IL10 and periodontal disorder.