In this study, we aimed, therefore, to assess the cost-effectiveness in two tropical lower-middle income countries, one in southeast Asia (Cambodia) and one in south Asia (Bangladesh), of a novel putative multiplex LF-RDT which measures CRP in addition to being able to diagnose acute enteric fever (e.g., by detecting typhoidal Salmonella antigens) and dengue (e.g., by detecting dengue NS1 antigen and dengue IgM) in patients with acute NMFI, in line with the results of the abovementioned Delphi survey. The gene discussed is CRP; the disease is dengue disease.