Furthermore, adiponectin may have a direct impact on tumor development because it plays certain roles in regulating hematopoiesis and the immune system, suppressing the growth of myelomonocyte cell lines, causing apoptosis in myelomonocytic progenitor cells, modulating gene expression associated with apoptosis in M1 cells, and reducing expression of the Bcl-2 gene [36]. The gene discussed is BCL2; the disease is neoplasm.