GNRH1 and endometrial cancer: Unlike GNRH1, GNRH2 is commonly expressed in a variety of adult human peripheral tissues but is seldom found in brain regions associated with gonadotropin secretion,46 suggesting it might not function as a hormone in the same way GNRH1 does. Furthermore, it was observed that GNRH2 had an anti-proliferative effect on prostate, ovarian, breast, and endometrial cancer cells.47