Notably, several gene symbols such as PNPLA3 on Locus 22q13.31 (associated with AFLD-CAD, NAFLD-CAD, NAFLD-HF), RP11-136O12.2 on Locus 8q24.13 (associated with NAFLD-CAD, NAFLD-Hypertension, NAFLD-HF), APOE and APOC1 on Locus 19q13.32 (associated with AFLD-CAD, NAFLD-CAD), and SHROOM3 on Locus 4q21.1 (associated with AFLD-CAD, AFLD-Hypertension) were found to be associated with multiple pairs. The gene discussed is APOE; the disease is metabolic dysfunction-associated steatotic liver disease.