The significant expression of SHROOM3 on locus 4q21.1 in relation to AFLD-Hypertension (P = 3.26E-08, PP.H4 = 0.956) and AFLD-CAD (P = 2.65E-09, PP.H4 = 0.968) should be noted. The gene discussed is SHROOM3; the disease is coronary artery disorder.