There is growing evidence that many of the gain-of-function effects of mutp53 depend on its ability to bind and inactivate the p53-associated proteins p63 and p73, wherein the p53 gain-of-function enhances cellular self-renewal and promotes the expression of cancer stem cell-associated genes, significantly contributing to invasion, metastasis, and chemo-resistant survival/multidrug resistance through activation of these genes.7 The gene discussed is TP53; the disease is cancer.