TP53 and cancer: The expression of TP53 is triggered by a variety of cellular stressors, including irradiation-induced DNA damage, hyperthermia, cytotoxic drugs, and oncogenic stress.9, 10, 11, 12 A multitude of biological processes, including cell cycle arrest, apoptosis, cell senescence, cell differentiation, angiogenesis, cell migration, metabolism, and DNA repair, are regulated by the wild-type p53 protein.13, 14, 15, 16 TP53 mutations are detected in around 60% of cancer cases according to a pan-cancer analysis of the TCGA database17.