,51,73,74 Recombinant human p53 adenovirus can be injected into the tumor tissue in an interventional manner to infect and transfect tumor cells with the TP53-carrying virus, followed by local injection of chemotherapeutic agents such as bleomycin or 5-fluorouracil and administration of systemic intravenous chemotherapy. The gene discussed is TP53; the disease is neoplasm.