Ad-p53 has also been used alone or in combination with radiotherapy, chemotherapy, thermotherapy, or other treatment options for other types of advanced cancer, including prostate cancer, soft tissue sarcoma, thyroid cancer, malignant glioma, and pancreatic cancer.66, 67, 68 Treatment with rAd-p53 has been reported to be safe and typically offers clinical benefit, even though the method of treatment varied across studies. This evidence concerns the gene TP53 and thyroid cancer.