TP53 and cancer: ,27 A variety of putative p53-mediated tumor suppression mechanisms have been described, such as inhibiting cell growth,28,29 reducing metastasis,30 regulating metabolic switching,31 remodeling the cancer immune microenvironment,32 and inducing cancer cell apoptosis,33, 34, 35, 36 autophagy,37 ferroptosis,38 and cellular senescence.39