PPARG and obesity due to melanocortin 4 receptor deficiency: Li et al106 studied the effects of bisphenol A diglycidyl ether, an antagonist of PPARγ, on an OVX rat model and showed that early treatment with a 30 mg/kg dose of bisphenol A diglycidyl ether reduced bone marrow obesity and stimulated bone formation in ovary-intact and OVX rats.