Also, it has been reported that bortezomib can induce increased transcription and post-translation of cyclin-dependent kinase p21 and p27 in hepatocellular carcinoma, non-small cell lung cancer, breast cancer,178,179 and pancreatic cancer,180 which leads to growth inhibition and apoptosis in those tumor cells.117. The gene discussed is CDKN1B; the disease is breast carcinoma.